Moreover, another study analyzed both protein levels and proteolytic activity of 9 MMPs (MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-13, MMP-14, and MMP-15) and TIMP-1, TIMP-2, and TIMP-3 in normal cervical tissue and LSIL, HSIL and cervical cancer clinical samples using IHC assays and gelatin zymography. This evidence concerns the gene TIMP2 and cervical cancer.