In summary, (I) tumor cells mainly expressed integrin α6β4 laminin receptors and (II) tumor-associated fibroblasts showed higher levels of laminin-α1 and laminin-β1 and lower levels of laminin-5, fibronectin, collagen III, TIMP-1 and the hyaluronan (HA) receptor CD44 when compared with normal fibroblasts 78. This evidence concerns the gene TIMP1 and neoplasm.