Notably, DM2 and cancer share many risk factors, especially obesity 12, and DM2 and malignancies are correlated through several conditions, such as hyperinsulinemia (due to resistance to endogenous or exogenous insulin), hyperglycemia, and chronic inflammation due to overweight and body fat mass 10,12. The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.