NTF3 and infection: Our results clearly demonstrated that lysolecithin-induced transient demyelination could effectively reduce the myelin sheath barrier and facilitate AAV-NT-3 entry, simultaneously avoiding excessive inflammation, secondary cell death, vascular disruption, infection of other cell types (e.g., glial cells), and the release of inhibitory molecules in the lumbar spinal cord (Hollis and Tuszynski, 2011).