SOX2 and neoplasm: These factors constitute the core embryonic transcription factor machinery.11, 12, 13 Pivotal work by Takahashi et al14 showed that SOX2 and OCT4, together with KLF4 and c‐MYC could reprogram human somatic cells to pluripotent stem cells.15 The ability of these factors to confer stemness would have major clinical implications, whereby their re‐expression in adult CSCs could result in a more aggressive tumor phenotype.