CD44 and colorectal cancer: CD44 signaling has been shown to modulate the tumor microenvironment and promote EMT‐related events through its involvement in processes like cell trafficking, lymph node homing, cell‐ECM adhesion, and coordination of cytokine signaling.51 Strikingly, there is also growing evidence projecting CD44 to be a marker of CSCs in the breast, prostate, pancreas, ovarian, and colorectal cancers.52, 53 While CD44 has been thought to have a strategic role in PCa progression, the exact mechanism involved is still largely unknown.