AR and neoplasm: While AR signaling is critical for the normal development, function, and homeostasis of the prostate gland, it is also thought to play a major role in PCa pathogenesis.41, 42 There is accumulating evidence suggesting that the androgen‐deprivation therapy initial therapeutic approach aimed at modulating AR signaling, results in the expansion of CSCs.26, 43, 44 These CSCs which survive through conventional therapies are thought to contribute toward treatment failure and tumor recurrence—clinical challenges associated with PCa therapy.