Also, it is a fact that the most frequent form in SpA, in which uveitis appears, is AS, and that uveitis may precede this diagnosis, may be concomitant with this diagnosis or it may appear anytime during the disease course [26] (the cumulative incidence of new uveitis over 2 years in a SpA cohort was 3.1% [27]), even as a paradoxical manifestation of tumour necrosis factor alpha (TNFα) inhibitors [28]. The gene discussed is TNF; the disease is uveitis.