Six (22%) of the Grade 3/4 related SAEs to be reported by more than one patient were increased alanine amino transferase (n = 4), pyrexia (n = 3), thrombocytopaenia (n = 3), hypoxia (n = 2), lung infection (n = 2) and neutropaenia (n = 2). The gene discussed is GPT; the disease is Fever.