Moreover, as summarized by Pudenz et al. 14, in vitro data suggests an impact of soy isoflavones on GSTP1, SCGB3A1 (HIN-1), TERT, BRCA1, BRCA2, ATM, APC, PTEN and SERPINB5 promoter methylation and BRCA1 (exon 1) and BRCA2 (exon 2) exon methylation in breast (cancer) cells15. This evidence concerns the gene SERPINB5 and cancer.