Another recent paper by Friederike Zunke et al. 48 highlighted the role of GlcCer accumulation in synuclein conformers formation, however the increase of GlcCer and the GlcCer/GalCer ratio assessed in 26 PD patients with different disease stages by LC-MS/MS, indicated a trend not statistically significant, suggesting that the interindividual variability of these molecules is high and a number of other molecules should be associated to link their variation to disease progression49. This evidence concerns the gene SNCA and Parkinson disease.