In LTC-IC assays performed on BMPR1BHi and BMPR1BLo LSC, more LTC-IC were present in the presence of BMP2/4 and following IM and IM/IFNα treatment in the BMPR1BHi LSC, indicating the BMP signalling pathway has an important role in LSC maintenance and CML disease persistence18. Here, BMP2 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.