Most importantly, the results of our study show that low expression of NDRG2 is associated with poorer OS and DFS in SACC patients, suggesting that NDRG2 plays a critical role in maintenance of the proliferative and metastatic characteristics of SACC and has the great potential to be a new molecular target in treating metastatic tumors. This evidence concerns the gene NDRG2 and metastatic neoplasm.