Besides its role in the differential diagnosis of thoracic tumors, HMB45 and MelanA expression has been demonstrated in sex-chord stromal tumors [26], t(6;11)(p21;q12)-translocation associated renal cell neoplasms [27], endometrial stromal sarcomas [28] and nerve sheet tumors [29]. This evidence concerns the gene PMEL and neoplasm of thorax.