Therefore, we systematically analyzed the expression of HMB45, MelanA, SOX10, CK5/6, NapsinA, p63 and TTF-1 in 1027 NSCLC cases including 498 adenocarcinomas (ADC), 424 squamous cell carcinomas (SqCC), 44 adenosquamous carcinomas (ADSqCC), 51 large cell carcinomas (LC) and 10 pleomorphic carcinomas (PC). This evidence concerns the gene SOX10 and large cell carcinoma.