In addition, amino acid sequence polymorphism within the Western EPIYA-B motif also influences CagA activity, as strains harboring EPIYT-B motif have attenuated ability of inducing hummingbird phenotype and IL-8 in gastric epithelial cells and confer less gastric cancer risk than strains harboring EPIYA-B motifs [29]. This evidence concerns the gene S100A8 and gastric cancer.