Previous studies showed cagA gene was found more frequently (p < 0.05) in the biopsies of gastric high-grade B cell lymphoma (76.7%, 23/30) compared to the gastritis (30.3%, 17/56) and the low-grade lymphoma of the mucosa associated lymphoid tissue (MALToma) cases (37.8%, 14/37) [52]. This evidence concerns the gene S100A8 and MALT lymphoma.