A case-control study showed Infection with strains “triple-positive” for cagA, vacAs1 and babA2 genes significantly correlates to the development of peptic ulcer (p < 0.0001) and adenocarcinoma (p = 0.014) and discriminated adverse disease outcome better than did the dual-positive (cagA and vacA1) classification [47]. The gene discussed is S100A8; the disease is peptic ulcer disease.