PCSK9 and coronary artery disorder: Recently, several PCSK9 inhibitors, such as alirocumab and evolocumab, were applied in patients with familial hypercholesterolemia and/or CAD in different countries, and were verified to decrease total cholesterol (TC), LDL-C, triglyceride (TG) and the ratio of TC to high-density lipoprotein cholesterol (HDL-C) greatly [6].