In subsequent studies [54], repeated administration of IL-33 accelerated tumor growth at the primary orthotopic sites and increased metastasis to the lungs and liver through increased accumulation of immunosuppressive CD11b+Gr-1+TGF-β1+ myeloid derived suppressor cells (MDSCs), IL-13-producing Lin−Sca-1+ST2+ innate lymphoid cells (ILCs), and CD4+Foxp3+ST2+IL-10+ regulatory T (Treg) cells. The gene discussed is IL33; the disease is neoplasm.