HGF and neurofibromatosis type 1: Dermal factors have also been identified to be abnormally expressed in pigmentary lesions, such as KGF/FGF7, HGF and SCF in lentigo senilis [127,128] and an increased secretion of SCF and HGF by dermal fibroblasts in neurofibromatosis type 1 (NF-1) disease [129].