Quite unexpectedly, while the majority of T-cell responses observed upon infection with DENV were directed against the nonstructural proteins NS3, NS4B, and NS5, ZIKV-specific T cells preferentially recognize structural proteins E, prM, and C, with conserved epitopes between DENV and ZIKV representing the main targets for cross-reactive T cells [22,23]. This evidence concerns the gene KRAS and infection.