For instance, six out of eight DENV/ZIKV-immune donors with a Neut50 value higher than 1500 revealed a moderate/low ADE activity (peak titer ≥ 450) on ZIKV infection and a moderate/high T-cell response (mean SFC/106 PBMC ≥ 100) against E, NS1, NS3, or NS5 (donors 16, 20, 28, 55, 63, and 66). The gene discussed is RAF1; the disease is Zika virus infectious disease.