Furthermore, we identified that the phosphorylation of Ser342 is critical for p50 homodimer assembly, and that Nfkb1−/− mice with a serine to alanine mutation at position 342(S342A) display increased neutrophil numbers, neutrophil chemokine expression, and increased tumour burden in the DEN HCC mouse model. Here, NFKB1 is linked to neoplasm.