Additionally, increased p50 and Bcl-3 expression in HRS and ALCL cell lines are mainly in the nuclear fractions verified by co-immunoprecipitation and is associated with increased expression of the anti-apoptotic genes Bcl-xL, c-IAP2, and TRAF-1 in the HRS cell lines [45]. The gene discussed is BCL3; the disease is anaplastic large cell lymphoma.