Overexpression of p105 along with p100 in cervical carcinoma-derived keratinocytes expressing the HPV16 oncoproteins E7 or E6, show localisation is predominantly cytoplasmic when E7 is expressed, and nuclear in the case of E6; therefore, these viral oncoproteins may actually dictate the subcellular localisation of p105 and p100 and hence activity of p105 and p100 [52]. This evidence concerns the gene NFKB1 and cervical carcinoma.