AKT1 and gastric cancer: However, metabolic subtype seems to be more sensitive to 5-fluorouracil than the other two, perhaps in relation to low levels of thymidylate synthetase, while the mesenchymal subtype (probably due to “oncogenic addiction” to PI3K-AKT-mTOR pathway, as we discuss above) seems to be sensitive to several drugs that block PI3K or mTOR, opening the way for a more precise therapy for GC.