TP53 and cancer: In addition to the known mutated driver genes (TP53 frequent in both subtypes, ARID1A in Epstain Barr Virus-related (EBV) or microsatellite instability-related cancers and CDH1 in diffuse-type), authors have been able to describe new highly recurrent significant mutations (i.e., MUC6, CTNNA2, GLI3, RNF4) and particularly the high prevalence of RHOA (Ras homolog gene family, member A) mutations in diffuse-type tumors (14.3% vs. 0% in the intestinal-type, p < 0.001).