ADORA2A and mastitis: Also, indolic alkaloids, such as Sinimenine and Oxymatrine, have shown protective effects in ameliorating tissue damage observed in models of acute lung injury and mastitis induced by LPS, associated with a decrease in neutrophil infiltrate, downregulation in the activation of NF-κB and MAPKs signal pathways [25,41], and upregulation of the A2A adenosine receptor (A2AR) [31].