Studies by our research group in a human colon cancer cell line revealed that EGCG inhibited transcriptional activities of AP-1 and NF-κB promoters, as examined by reporter assay and that treatment with either EGCG or PolyE caused inhibition of AP-1 and NF-κB luciferase reporter activities [44,71]. This evidence concerns the gene NFKB1 and malignant colon neoplasm.