These two variants, BRCA1:c.‐192T>C and BRCA2:c.‐296C>T, were observed in population subgroup controls; notably BRCA1:c.‐192T>C was observed at a frequency of >1%, which is considered stand‐alone evidence against pathogenicity (defined as high risk of cancer) for BRCA1/2 variation. The gene discussed is BRCA1; the disease is cancer.