We analyzed a total panel of 8 genes: RARβ2, TIMP3, SPARC, and CYB5R2 that we have previously demonstrated to be most differentially hypermethylated in PCa in AA and EA men [16] and LINE1, HIN1 and CDH13 that we have also shown to be most differential hypermethylated in Breast cancers from AA and EA women [24]. This evidence concerns the gene CYB5R2 and breast cancer.