In the cancer cases, we observed significant and inverse correlation of serum vitamin D levels and DNA methylation of CDH13 (p = 0.045; r = -0.210; Fig 3C) and significant and inverse correlation of supplementary vitamin D for TIMP3 (p = 0.022; r = -0.24; Fig 3D) and DRD2 (p = 0.056; r = -0.201; Fig 3E) promoter DNA methylation. This evidence concerns the gene DRD2 and cancer.