Similar results were observed even when adjusting for statin treatment only, or adjusting for statin treatment and diabetes further supporting the association between circulating TRAIL levels and the formation of at least two new plaques in all territories (OR = 0.77 (0.60–0.99), p = 0.046 and OR of 0.78 (0.61–1.00), p = 0.054, respectively). This evidence concerns the gene TNFSF10 and diabetes mellitus.