IL-10 produced by activated macrophages and T-cells exerts various effects that are principally anti-inflammatory and immunosuppressive in nature.[33] In the eye, IL-10 may be associated with an angiogenetic response to hypoxia, but the details remain unclear.[34, 35] IL-10 levels in aqueous humor are elevated in patients with diabetes, retinal vascular occlusion, or primary intraocular lymphoma.[36–38] However, few IL-10 data are available for DME patients, and the results vary. Here, IL10 is linked to diabetes mellitus.