In contrast, Haidari et al. showed that β1-integrin-mediated adhesion of MDA-MB-231 and PC-3 cells onto HUVECs induces Tyr phosphorylation of vascular endothelial (VE)-cadherin, dissociation of catenin from the VE-cadherin complex and retraction of endothelial cells which facilitates transendothelial migration of tumor cells. This evidence concerns the gene CDH5 and neoplasm.