This study shows an important role for TRPV1+TRPA1+SP/CGRP+ sensory nerves in mediating both skin pathology and associated cutaneous discomfort in the Aldara model of psoriasis, consistent with previous clinical evidence for the potential of sensory nerves to influence skin lesions and consequential cutaneous discomfort complications in this disease (3, 42). This evidence concerns the gene TRPV1 and psoriasis.