There were also no significant changes in the expression of TLR7 and TLR3, both previously shown to mediate pruritus (59, 60) in Aldara or sensory-denervated groups, suggesting that the reduction in spontaneous behaviors was unlikely to be due to the loss of the expression of those receptors in the DRG and possibly mediated by other sensory mediators. The gene discussed is TLR7; the disease is Pruritus.