Importantly, disease progression and clonal evolution in the biological continuum from the early cancer stages (ET/PV) along the path towards the advanced myelofibrosis stage have been closely linked to the development of additional subclonal mutations (ASXL1, SRSF2, CBL, IDH1/IDH2, TP53, and SRSF2), being independently associated with leukemic transformation and poor survival [69, 152, 160]. Here, SRSF2 is linked to cancer.