IFNL3 and myeloproliferative neoplasm: Highly interestingly, Andreassson et al. have recently shown that variation in IL28B genotype influences hematologic response in IFN-alpha2-treated MPN patients [50] similar to the response to IFN-alpha2 treatment of chronic hepatitis C, which has been shown to be strongly influenced by several related single nucleotide polymorphisms (SNP) in a region adjacent to the IL28B gene [182].