Differences between IDH-mut non-codel or IDH-mut codel and IDH-wt gliomas exhibited the highest effect size (with P < 0.001) for Slope15–40 (r = 0.38, AUC = 0.75, for T = − 0.4 SUV/h: Se = 74%, Sp = 69%; r = 0.34, AUC = 0.75, for T = − 0.4 SUV/h: Se = 73%. The gene discussed is IDH1; the disease is glioma.