However, in the case of IDH-wt gliomas, the fraction of voxels with an early peak (PVHTTP < 20: P = 0.035, r = 0.29) and negative slope (PVHSlope < 0: P = 0.010, r = 0.33) was significantly higher in WHO grade III compared to that in WHO grade IV gliomas. Here, IDH1 is linked to central nervous system cancer.