IRF1 and polycystic ovary syndrome: Since the menstrual cycle and its disturbances are an important part of PCOS symptoms, we additionally performed a look-up of the reported PCOS susceptibility loci (15–19) and observed nominally significant (P < 0.05) associations with five loci (FSHB, FSHR, RAB5B/SUOX, IRF1/RAD50 and KRR1) (Supplementary Material, Table 4).