The content is based on a PubMed literature search covering the years 1960–2017 and using the search terms “angiogenesis inhibitor, arterial thrombotic events, atherosclerosis, cancer, cardiomyopathy, cardiotoxicity, chemotherapy, coronary artery disease (CAD), diabetes, heart failure, hypertension, hypothyroidism, obstructive sleep apnea (OSA), preeclampsia, vascular, VEGF, and VEGF inhibitor.” This evidence concerns the gene VEGFA and hypothyroidism.