One experimental study evaluating the effect of sorafenib in mice subjected to myocardial infarction did not find evidence of any alteration of post-myocardial infarction neovascularization or fibrosis.28 However, sorafenib led to apoptosis of cardiac- and bone-derived c-kit+ stem cells, thereby decreasing endogenous cardiac repair capacity. Here, KIT is linked to myocardial infarction.