VEGFA and neoplasm: Angiogenesis inhibitors have turned into clinical reality the pioneering vision of Dr. Judah Folkman’s that new blood vessel formation is critical for the growth of tumors and that anti-angiogenic therapy is key to tumor regression.1 Bevacizumab, a humanized monoclonal antibody directed against all isoforms of vascular endothelial growth factor (VEGF)-A, was the first targeted angiogenesis inhibitor to be developed.