This beneficial effect was related to the robust expression of VEGF receptor 1 on endothelial cells in the myocardium.117 Of note, following myocardial infarction, prolonged intramyocardial expression of VEGF-A165 and VEGF-B167 preserves viable cardiac tissue, prevents ventricular remodeling, and results in improved cardiac function over time. Here, VEGFA is linked to myocardial infarction.