Serum SCUBE1 levels in patients with PCOS stratified according to hyperandrogenism were not statistically different from one another (5.8±2.8 ng/mL in normoandrogenic PCOS vs. 5.9±3.1 ng/mL in hyperandrogenic PCOS, p=0.91). This evidence concerns the gene SCUBE1 and polycystic ovary syndrome.