There are also studies in which the anti-TNF inhibitor infliximab has been used as a biological agent.18 In one report, a 61% remission rate was achieved in neurosarcoidosis by discontinuing corticosteroids and treating with methotrexate.14 In the present case, full remission with no recurrence during the 15-month follow-up period was achieved with methotrexate treatment. The gene discussed is TNF; the disease is neurosarcoidosis.