AKT1 and gastric cancer: (2) effect of SHP-1 on downregulation of phosphoinositide 3-kinase (PI3K)/Akt pathway in gastric cancer since SHP-1 might have potential to modulate other signaling pathways such as nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and PI3K/Akt pathways via dephosphorylation of receptor tyrosine kinases [5, 35].