Results showed that compared to those in healthy controls, levels of NEK7, NLRP3, and ASC were lower (p = 0.0004, Fig. 1a; p = 0.0001, Fig. 1b; p = 0.0005, Fig. 1c, respectively), whereas Caspase-1, IL-1b, and IL-18 were higher in SLE patients (p = 0.0001, Fig. 1d; p = 0.0001, Fig. 1e; p = 0.0001, Fig. 1f, respectively). The gene discussed is CASP1; the disease is systemic lupus erythematosus.