Our precious study showed that the expression of SH2B1 was significantly higher in NSCLC tissues compared with their normal counterparts and was positively correlated with late-stages NSCLC patients and shorter survival time, which strongly indicated that SH2B1 may be a target molecule for blocking aberrant progression of NSCLC [4]. The gene discussed is SH2B1; the disease is non-small cell lung carcinoma.