CD68 and colorectal carcinoma: For CD68, the normalized number of positive macrophages was 2.08-fold higher in the CRC invasive front in comparison of the number of positive cells observed at the center of the tumor (p < 0.0001; paired t-test) and 1.45 in ENE invasive front in comparison to the matched ENE-negative LNs (p = 0.015; paired t-test).