CD8A and neoplasm: For CD8, the normalized number of positive T-cells was 3.04-fold higher in the CRC invasive front in comparison of the number of positive cells observed at the center of the tumor (p < 0.0001; paired t-test) and 1.74 in ENE invasive front in comparison to the matched ENE-negative metastatic LNs (p = 0.008; paired t-test).