For CD4, the normalized number of positive T-cells was 1.82-fold higher in the CRC invasive front in comparison of the number of positive cells observed at the center of the tumor (p = 0.0026; paired t test) and 1.71 in ENE invasive front in comparison to the matched ENE-negative metastatic LNs (p = 0.029; paired t-test). Here, CD4 is linked to neoplasm.