The four cases with MMRd presented a relatively, but not significant, higher number of CD4 and CD8 infiltrating cells (in both primary and metastatic LNs) in comparison to MMR proficient (MMRp) cases, and were also characterised by a higher number of CD4/CD8 positive cells at both the CRC invasive front in comparison to the center of the tumor and in ENE invasive front in comparison to the matched ENE-negative metastatic LNs. The gene discussed is CD4; the disease is neoplasm.