SMC4 and cancer: The qRT-PCR results confirmed the down-regulation of the mitotic cell cycle regulators such as CDK2 and SMC4 in both lung and glioblastoma SOX2OT knocked down cancer cell lines, while the CDK2AP2 which is also known to interact and inhibit CDK2 [33], is up-regulated more than two times in treated cells (Fig. 3b).