Since Runx2 directly regulated Fgfr2 and the knockdown of Fgfr2 was effective for inhibiting the proliferation of osteoblast progenitors, the regulation of FGFR2 by RUNX2 may also play an important role in the development and progression of some breast cancers by enhancing cell proliferation. The gene discussed is FGFR2; the disease is breast cancer.