When further adjusted for age, sex, eGFR, admission cardiac medications (beta blocker, renin-angiotensin blockade and statin use) and atrial fibrillation status, the OR for 6-month mortality in the diabetes group compared to no diabetes remained similar at 0.11 (0.03–0.42, p = 0.001) whilst in the pre-diabetes group, the OR dropped further to 0.22 (0.06–0.85, p = 0.03) and this time reached statistical significance. The gene discussed is REN; the disease is diabetes mellitus.