This analysis highlights potential oncogenic tumour promoting roles for the actin binding protein encoded by FLNB and the histone methyltransferase encoded by WHSC1, as expression of both of these genes are elevated during cSCC progression and they do not contain premature termination codon or splice site mutations (Fig. 5 and Supplementary Fig. 6, 7). This evidence concerns the gene FLNB and neoplasm.