HERC6 and neoplasm: Among them, TP53 and NOTCH2 were downregulated in SCC compared to normal skin, while seven genes HERC6, CDKN2A, FLNB, MAP3K9, TMEM51, MAPK1IP1L and WHSC1 were upregulated in SCC relative to normal skin in at least 3 out of 5 data sets (Fig. 5b) suggesting respective potential tumour suppressing and tumour promoting roles in cSCC development.