MSS cancers also showed strong preference of TP53 and SMAD4 losses (genome-wide-corrected logistic model, p < 10−5), whereas aberrations in MSI CRCs occurred preferably at common fragile sites FHIT (Logistic model, p < 10−5), RBFOX1 (p < 10−5), WWOX (p < 0.02), and MACROD2 (p < 0.05) (Supplementary Table 1). This evidence concerns the gene SMAD4 and cancer.