TCF7L2 and cancer: More generally, the genome-wide results highlight the particular importance of the AI target genes for CRC: of the 17,670 genes measured, six of the top ten genes that the CRC cell lines were particularly dependent on (versus other cancer cell lines) were in the AI peaks: TCF7L2, SATB2, KRAS, KLF5, CCND2, and DBF4 (Fisher’s exact test p < 2 × 10−7).