The three most frequently gained loci in the whole data set were HNF4A in 803 or 47% of 1699 cancers, KLF5 (709 or 42%) and MYC (585 or 34%) (Fig. 1b), all of which have previously been implicated as amplification targets in CRC8,13,14. The gene discussed is HNF4A; the disease is cancer.