For example, frequent losses at SOX9 (seen in more than one third of all samples, Table 1) and the observed growth inhibition in the CRISPRa assay are compatible with selection of reduced SOX9 expression while the gene was consistently overexpressed in the RNA-seq data from the surgically removed full-blown cancers in both cases with AI, as well as those without (Supplementary Figure 18). This evidence concerns the gene SOX9 and cancer.