Analysis of the mutation burden in these 42 genes, and 42 genes associated with CRC in the COSMIC cancer gene census (total of 74 unique genes), showed that the point mutation rate in MSS tumors rivaled the rate of respective chromosomal aberrations in only APC, KRAS, and TP53 (Supplementary Figure 10). The gene discussed is TP53; the disease is colorectal carcinoma.