Similar to 9-cis-retinoic acid, a compound that ameliorates AKI through inhibition of NUR7745, all-trans-retinoic acid (tretinoin) improved the renal function after I/R injury in both control and Myc-deficient mice, underlining the pleiotropic effects of this reagent on energy metabolism independent of Myc. The gene discussed is MYC; the disease is acute kidney injury.