PARD6B and cyst: In addition, neither knockdown of zebrafish celsr117, a core component of the non-canonical Wnt/planar cell polarity pathway, nor depletion of par6b, a component of the apico-basal polarity complex, interfered with the repair process despite extensive morphological abnormalities of the pronephros, including cyst formation and duct dilatations (Supplementary Fig. 4c)18.