A local 13.56 MHz radiofrequency hyperthermia after i. v. injection of transferrin increased the temperature of the cancer tissue of the mice by 10.3 °C, while the temperature only increased by 4.3 °C for the apotransferrin-treated group (Fig. 2 and see Supplementary Figs 3 and 6). The gene discussed is TF; the disease is cancer.