To investigate the level and kinetics of platelet activation during sepsis we analyzed platelet intrinsic markers including membrane exposure of CD62P and fluorescently labeled fibrinogen binding to activated GpIIbIIIa (αIIbβ3), formation of heterotypic aggregates between platelets and leukocytes and soluble markers in plasma such as soluble CD40L (sCD40L) and eicosanoids. This evidence concerns the gene CD40LG and Sepsis.