NLRP3 and graft versus host disease: The allogeneic [WT B6Ly5.2 → Nlrp3−/−] chimeras that lacked NLRP3 on host non-hematopoietic target tissues demonstrated significantly greater severity of GVHD (P = 0.001) compared with [WT B6 → WT B6Ly5.2] recipients (Fig. 6c, d).