In addition to promoter DNA methylation, RASSF1A inactivation had been shown to be associated with a repressive chromatin configuration with histone deacetylation and H3K9 dimethylation in prostate cancer cell lines29.Nonetheless, in primary lung, liver and renal cancer tissues, RASSF1A inactivation has been consistently shown to be mediated by promoter DNA methylation, hence an important role in the regulation of RASSF1A expression30. Here, RASSF1 is linked to Familial prostate cancer.