The zoometric, metabolic, and biochemical changes observed in the rats of the Cd group were in concordance with significant hyperinsulinemia (75%), the development of insulin resistance demonstrated by HOMA-IR (216%), and insulin resistance adipocyte dysfunction (IDA-IR; 557%), as well as a significant loss of hepatic insulin sensitivity (HIS; 72%) (Table 1). This evidence concerns the gene INS and hyperinsulinism.