In animal models, the hyperglycemia produced by Cd has been related with significant increases in the hepatic transporter GLUT2, carbohydrate regulatory element binding protein (ChREBP), and mRNAs of glucokinase and pyruvate kinase [50], as well as by a downregulation of the expression of the glucose transporter GLUT4 in both muscle and adipocytes. This evidence concerns the gene GCK and Hyperglycemia.