LEP and metabolic syndrome: Obesity and T2DM belong to a very complex group of genetic and epigenetic diseases with a socio-environmental influence known as chronic non-communicable diseases, that have a common background: metabolic disturbances or metabolic syndrome associated with dysglycemia, dyslipidemia, dyslipoproteinemia, and arterial hypertension, as well as hormone imbalance of insulin, leptin, adiponectin, and resistin, which affect other hormonal axes, contributing to alterations of triglycerides and glycogen in several tissues [25,26,27].