Inhibitor of apoptosis proteins (IAPs) are anti-apoptotic proteins including cIAP1 (cellular inhibitor of apoptosis protein-1), cIAP2 (cellular inhibitor of apoptosis protein-2), XIAP and ML-IAP (melanoma inhibitor of apoptosis protein), and facilitate treatment resistance by inhibiting caspase activation [23]. This evidence concerns the gene BIRC2 and melanoma.