The levels of pro-apoptotic Bax and cleaved caspase-3 were enhanced, and Bcl-2 expression was downregulated from leucine-rich α2 glycoprotein 1 (LRG1)-silencing, which inhibited the growth of xenograft tumors and induced apoptosis of U251 glioblastoma cells in vitro and in vivo [28]. The gene discussed is LRG1; the disease is glioblastoma.