The expressions of cell cycle regulator Cdk1 (cyclin-dependent kinase 1) and anti-apoptotic protein Bcl-2 were decreased, and the expression of Bax and cleavage of PARP (poly ADP ribose polymerase) proteins were increased by the synergistic effects of the epigenetic agent PEITC and the chemotherapeutic agent paclitaxel (taxol) in breast cancer cells [5]. This evidence concerns the gene CDK1 and breast cancer.