In the azoxymethane (AOM)-initiated and dextran sodium sulfate (DSS)-promoted-C57BL/6 mice colon cancer model, PEITC inhibited colon tumor multiplicity and intestinal polyp development, and reduced intestinal tumor size associated with apoptosis (enhanced cleaved caspase-3 and-7) and cell cycle arrest (elevated p21) [16]. This evidence concerns the gene CASP3 and colonic neoplasm.