SIRT1 and metabolic dysfunction-associated steatotic liver disease: Through its antioxidative capabilities, silymarin can restore NAD+ homeostasis, Sirtuin 1 (SIRT1) activity, and the AMP-activated protein kinase α (AMPKα) pathway to improve poly-(ADP-ribose)-polymerase (PARP) function, which protects the cell from the oxidative damage observed in NAFLD [22].