NPPB and heart failure: We examined cardiac expression of Nppb, Timp1 and Lgals3, which are transcripts encoding three well-known heart failure plasma biomarkers brain natriuretic peptide (BNP), tissue inhibitor of metalloproteinase 1 (TIMP1), and galectin-3 (de Boer, Voors et al. 2009, Goldbergova, Parenica et al. 2012, Ho, Liu et al. 2012).