In this regard, it was observed in a study comparing GPNMB-deficient DBA/2J mice and their coisogenic DBA/2J-GPNMB+ relatives, that GPNMB appeared to confer increased risk of adverse ventricular modeling with left ventricular dilation and a decrease in fractional shortening after myocardial infarction (Järve et al. 2017). This evidence concerns the gene GPNMB and Vascular dilatation.